Yazar "Velioğlu, Halil Aziz" için listeleme
-
Alzheimer hastalarında lateral parietal korteks TMS uyarımın bellek işlevleri ve beyin bağlantısallığı üzerine etkisi
Velioğlu, Halil Aziz (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Alzheimer hastalığı (AH) tedavisinde kullanılan farmakolojik yaklaşımların etkin bir çözüm sunamaması tedavi için transkranyal manyetik stimülasyon (TMS) gibi invazif olmayan beyin uyarım yöntemlerinin hastalarda denenmesine ... -
Brain temperature in healthy and diseased conditions: A review on the special implications of MRS for monitoring brain temperature
Yulug, Burak; Velioğlu, Halil Aziz; Sayman, Dila; Çankaya, Şeyda; Hanoğlu, Lütfü (Elsevier Masson s.r.l., 2023)Brain temperature determines not only an individual's cognitive functionality but also the prognosis and mortality rates of many brain diseases. More specifically, brain temperature not only changes in response to different ... -
Chemogenetic inhibition of MCH neurons does not alter memory performance in mice
Mutlu Burnaz, Özlem; Yuluğ, Burak; Öncül, Merve; Çelik, Eşref; Sayar Atasoy, Nilüfer; Çankaya, Şeyda; Hanoğlu, Lütfü; Velioğlu, Halil Aziz (Elsevier Masson s.r.l., 2022)Memory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consolidation ... -
Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial
Hajebrahimi, Farzin; Velioğlu, Halil Aziz; Bayraktaroğlu, Zübeyir; Helvacı Yılmaz, Nesrin; Hanoğlu, Lütfü (Nature Research, 2022)There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases
Türkez, Hasan; Altay, Özlem; Yıldırım, Serkan; Li, Xiangyu; Yang, Hong; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Arif, Muhammad; Yuluğ, Burak; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Hacımüftüoğlu, Ahmet; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Borén, Jan; Uhlén, Mathias; Mardinoğlu, Adil (Elsevier Inc., 2023)Background: Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data and animal studies ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
Ayyıldız, Sevilay; Velioğlu, Halil Aziz; Ayyıldız, Behçet; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yıldırım, Süleyman; Atasever, Alper; Yuluğ, Burak (Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients
Toprak, Güven; Hanoğlu, Lütfü; Çakır, Tansel; Güntekin, Bahar; Velioğlu, Halil Aziz; Yuluğ, Burak (Bentham Science Publishers, 2022)Background: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes ... -
The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model
Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakariş, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (University Press, 2022)Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative ... -
EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
Övey, İshak Suat; Özşimşek, Ahmet; Velioğlu, Halil Aziz; Altay, Özlem; Mardinoğlu, Adil; Yuluğ, Burak (Frontiers Media SA, 2023)Background: Transient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes. Moreover, there ... -
Evaluating the clinical significance of diazepam binding inhibitor in alzheimer's disease: A comparison with inflammatory, oxidative, and neurodegenerative biomarkers
Gökçe, Mustafa; Velioğlu, Halil Aziz; Bektay, Muhammed Yunus; Güler, Eray Metin (Karger, 2023)Introduction: Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. The aim of this study was the investigation of diazepam binding inhibitor (DBI) as a prognostic factor for ... -
The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
Yuluğ, Burak; Ayyıldız, Sevilay; Sayman, Dila; Karaca, Ramazan; İpek, Lütfiye; Çankaya, Şeyda; Salar, Ali Behram; Ayyıldız, Behçet; Mikuta, Christian; Yağcı, Nilay; Özdemir Öktem, Ece; Özşimşek, Ahmet; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (John Wiley and Sons Inc, 2024)INTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their ... -
Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
Yuluğ, Burak; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sayman, Dila; Salar, Ali Behram; Çankaya, Şeyda; Özdemir, Ece; Özşimşek, Ahmet; Kurt, Çağla Ceren; Lakadamyalı, Hatice; Aktürk, Aynur; Altay, Özlem; Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Mardinoğlu, Adil (John Wiley and Sons Inc, 2023)Although no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that ... -
Inherited epilepsies
Velioğlu, Halil Aziz; Bektay, Muhammed Yunus (Bezmiâlem Vakıf University, 2020)Mutations in genes encoding the formation of ion channels may cause epileptic syndromes. These epileptic syndromes are generally divided into generalized and partial epilepsies. Among the causative agents of generalized ... -
İnsan claustrum'unun fonksiyonel bağlantısallığının yaşlı bireylerde fMRG ile incelenmesi
Karasu, Sevilay (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Claustrum gizemli bir telencephalic gri cevher yapısıdır. İnce ve düzensiz bir şekle sahip olan claustrum cerebral cortex'te bilateral olarak bulunur. Bu subcortical yapı putamen ve insular cortex yapıları arasında uzanır. ... -
Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
Velioğlu, Halil Aziz; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Toprak, Güven; Güler, Eray Metin; Bektay, Muhammed Yunus; Mutlu Burnaz, Özlem; Yuluğ, Burak (Academic Press Inc., 2021)Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ... -
Neuroimaging-guided transcranial magnetic and direct current stimulation in MCI: Toward an individual, effective and disease-modifying treatment
Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Hanoğlu, Taha; Yuluğ, Burak (SAGE Publications Inc, 2023)The therapeutic approaches currently applied in Alzheimer's disease (AD) and similar neurodegenerative diseases are essentially based on pharmacological strategies. However, despite intensive research, the effectiveness ... -
Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia
Seçkin, Mustafa; Yıldırım, Elif; Demir, İlayda; Orhun, Ömer; Bülbül, Ezgi; Velioğlu, Halil Aziz; Öktem, Öget; Yeşilot, Nilüfer; Çoban, Oğuzhan; Gürvit, Hakan (Wiley, 2023)Background: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods: The ... -
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
Çankaya, Şeyda; Özdemir Öktem, Ece; Saatçi, Özlem; Velioğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Parkinson hastalarında telerehabilitasyon ile bilişsel rehabilitasyonun etkisi
Biçer, Begüm (İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Parkinson Hastalığı (PH), nedeni tam anlamıyla bilinmeyen, genel motor semptomları bradikinezi, kas rijiditesi, tremor ve postural instabilite olan ikinci en sık görülen nörodejeneratif hastalıktır. Bilişsel bozukluk PH'nin ...